The activation mechanism of class-C G-protein coupled receptors
نویسندگان
چکیده
منابع مشابه
Activation of G-protein-coupled receptors: a common molecular mechanism.
G-protein-coupled receptors (GPCRs) are a large family of proteins that contain a seven transmembrane helical structural motif. They mediate responses to several ligands by binding and activating intracellular heterotrimeric G proteins. Since the cloning of the first GPCR, insights gained from structure-function studies, genetics and drug development have contributed to uncovering a common mech...
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G protein-coupled receptors (GPCRs) are integral cell membrane proteins of relevance for pharmacology. The complete tertiary structure including both extracellular and transmembrane domains has not been determined for any member of class C GPCRs. An alternative way to work on GPCR structural models is the investigation of their functionality through the analysis of their primary structure. For ...
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G protein-coupled receptors (GPCRs) mediate responses to hormones and neurotransmitters, as well as the senses of sight, smell, and taste. These remarkably versatile signaling molecules respond to structurally diverse ligands. Many GPCRs couple to multiple G protein subtypes, and several have been shown to activate G protein-independent signaling pathways. Drugs acting on GPCRs exhibit efficacy...
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Denne afhandling er af Danmarks Farmaceutiske Højskole antaget til offentligt at forsvares for den farmaceutiske doktorgrad. For Anita, without whose support this would have been much harder. Preface i Preface No Man is an Island. This immortal phrase by John Donne also holds true when it comes to science. Thus the present thesis would not have been possible to write without the many fruitful c...
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The class B family of G protein-coupled receptors contains several potentially important drug targets, yet our understanding of the molecular basis of ligand binding and receptor activation remains incomplete. Although a key role is recognized for the cysteine-rich, disulfide-bonded amino-terminal domain of these receptors, detailed insights into ligand docking and resultant conformational chan...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2004
ISSN: 0248-4900
DOI: 10.1111/j.1768-322x.2004.tb01423.x